There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to decrease afferent pain transmission and deliver analgesia. As a result, drugs like clonidine that goal alpha-2 receptors can influence the transmission of discomfort. Relates to clonidine: oral tablet, https://popeh925ifa4.develop-blog.com/profile