Within the LSD-bound crystal framework, the facet chain from the lid residue L209EL2 types extensive hydrophobic contacts with both LSD and bordering residues in TMs III, IV, and V (Figure 4C). In the event the lid moved aside to reveal the binding pocket in simulation, various of these contacts broke. https://codyunqft.blogoxo.com/35287267/the-definitive-guide-to-lsd-crystal