Butabarbital decreases effects of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of CYP3A4 inducers may well lessen sufentanil degrees and efficacy, potentially precipitating withdrawal syndrome in patients who have made Actual physical dependence to sufentanil. Discontinuation of concomitantly employed CYP3A4... https://cordellw245jif4.yourkwikimage.com/user